Cooperative evolution of mechanisms of β-lactam resistance
نویسندگان
چکیده
منابع مشابه
β-Lactam Resistance and Enterobacteriaceae, United States
Extended-spectrum cephalosporins (ESC) are an important drug class for treating severe Salmonella infections. We screened the human collection from the National Antimicrobial Resistance Monitoring System 2000 for ESC resistance mechanisms. Of non-Typhi Salmonella tested, 3.2% (44/1,378) contained blaCMY genes. Novel findings included blaCMY-positive Escherichia coli O157:H7 and a blaSHV-positiv...
متن کاملDivergent mechanisms for passive pneumococcal resistance to β-lactam antibiotics in the presence of Haemophilus influenzae.
BACKGROUND Otitis media, for which antibiotic treatment failure is increasingly common, is a leading pediatric public health problem. METHODS In vitro and in vivo studies using the chinchilla model of otitis media were performed using a β-lactamase-producing strain of nontypeable Haemophilus influenzae (NTHi 86-028NP) and an isogenic mutant deficient in β-lactamase production (NTHi 86-028NP b...
متن کاملEvolution of fungal β-lactam biosynthesis gene clusters
Filamentous fungi are microorganisms of great biotechnological interest due to their ability to synthesize a variety of bioactive secondary metabolites including β-lactam antibiotics, such as penicillins and cephalosporins. Hydrophobic (with aromatic side chains) penicillins are only produced by fungi, mainly Penicillium chrysogenum and Aspergillus (Emericella) nidulans, whereas hydrophilic cep...
متن کاملDiastereoselective synthesis of potent antimalarial cis-β-lactam agents
Fifteen novel β-lactams bearing the N-ethyl tert-butyl carbamate group 5a-o and fifteen N-(2-aminoethyl) β-lactams 6a-o were synthesized by the ketene-imine [2+2] cycloaddition reaction (Staudinger ). The cycloaddition reaction was found to be totally diastereoselective leading exclusively to the formation of the cis-β-lactam derivatives. These newly synthesized β-lactams were evaluated for the...
متن کاملNovel mechanisms of resistance to β-lactam antibiotics in Haemophilus parainfluenzae: β-lactamase-negative ampicillin resistance and inhibitor-resistant TEM β-lactamases.
OBJECTIVES To determine the mechanisms of resistance to β-lactam antibiotics in clinical isolates of Haemophilus parainfluenzae. METHODS Twenty clinical isolates of H. parainfluenzae with decreased susceptibility to aminopenicillins were examined and compared with a control group of 20 fully susceptible isolates. In this collection, the presence of amino acid substitutions in the transpeptida...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2000
ISSN: 1198-743X
DOI: 10.1111/j.1469-0691.2000.tb02037.x